Renal Dose Adjustment & Kidney Function

Creatinine Clearance & Renal Dose Adjustment

Calculate eGFR / Creatinine Clearance (CrCl) using the Cockcroft-Gault equation. Pharmacists use CrCl to adjust doses of renally-cleared drugs like antibiotics, digoxin, metformin, and NSAIDs.

Patient Kidney Function Data

Age (years)

Weight (kg)

Serum Creatinine (mg/dL)

mg/dL

Normal: 0.7–1.3 mg/dL (Male), 0.5–1.1 (Female)

Patient Sex

Male

Female (×0.85)

CrCl Result & Dose Guidance

Creatinine Clearance (CrCl)

68.5 mL/min

Cockcroft-Gault Equation

Kidney Function Stage: Mild (CKD 2)

Dose Adjustment Needed: No (Standard Dose)

Metformin: Safe (>45 mL/min)

NSAIDs / Nephrotoxics: Use with caution

CKD Stage Reference:

>90	Normal / CKD 1
60–89	Mildly Reduced / CKD 2
30–59	Moderate / CKD 3
15–29	Severe / CKD 4
<15	Kidney Failure / CKD 5

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